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Our work

Published Papers

Below is a sample of published papers describing work wholly or partly funded by Action Against Cancer. Please click to enlarge the samples.

  1. LMTK3 regulation of EV biogenesis and cargo sorting promotes tumour growth by reducing monocyte infiltration and driving pro-tumourigenic macrophage polarisation in breast cancer
  2. Orchestrating the metastatic symphony: the role of extracellular vesicles in the epithelial-mesenchymal transition and pulmonary niche formation of breast cancer
  3. Combined multi-omics and multi-spectral profiling of plasma extracellular vesicles reveals liquid biopsy biomarkers for glioma diagnosis
  4. Modelling adipose tissue-cancer crosstalk: a three-dimensional perspective
  5. Cancer-associated fibroblasts as key regulators of lipid metabolism in the tumour microenvironment
  6. LMTK3 regulation of EV biogenesis and cargo sorting promotes tumour growth by reducing monocyte infiltration and driving pro-tumourigenic macrophage polarisation in breast cancer
  7. Spatial biology – unravelling complexity within the glioblastoma microenvironment
  8. Preserving Fossilized Soft Tissues: Advancing Proteomics and Unveiling the Evolutionary History of Cancer in Dinosaurs
  9. Unlocking the diagnostic power of plasma extracellular vesicle miR-200 family in pancreatic ductal adenocarcinoma
  10. Kinome-Wide Synthetic Lethal Screen Identifies PANK4 as aModulator of Temozolomide Resistance in Glioblastoma
  11. A bile-based microRNA signature for differentiating malignant from benign pancreaticobiliary disease
  12. The role of non-coding RNAs in extracellular vesicles in breast cancer and their diagnostic implications
  13. Comparison of phenomics and cfDNA in a large breast screening population: the Breast Screening and Monitoring Study (BSMS)
  14. Comparison of phenomics and cfDNA in a large breast screening population: the Breast Screening and Monitoring Study (BSMS)
  15. The Inhibitory Properties of a Novel, Selective LMTK3 Kinase Inhibitor
  16. Incorporating Immunotherapy in the Management of Gastric Cancer: Molecular and Clinical Implications
  17. LncRNAs in breast cancer: a link to future approaches
  18. PDGF-R inhibition induces glioblastoma cell differentiation via DUSP1/p38MAPK signalling
  19. Definition of an Inflammatory Biomarker Signature in Plasma-Derived Extracellular Vesicles of Glioblastoma Patients
  20. Tuneable synthetic reduced graphene oxide scaffolds elicit high levels of three-dimensional glioblastoma interconnectivity in vitro
  21. Reconstituting Immune Surveillance in Breast Cancer: Molecular Pathophysiology and Current Immunotherapy Strategies
  22. The multifaceted role of lemur tyrosine kinase 3 in health and disease
  23. LMTK3 inhibition affects microtubule stability
  24. Protein kinases play a pivotal role in regulating intracellular signal transduction
  25. Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping
  26. TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression
  27. LMTK3 confers chemo-resistance in breast cancer
  28. microRNAs with prognostic significance in pancreatic ductal adenocarcinoma: A meta-analysis, European Journal of Cancer
  29. LMTK3 Represses Tumor Suppressor-like Genes through Chromatin Remodeling in Breast Cancer, ECell Reports
  30. Characterization of the Tyrosine Kinase-Regulated Proteome in Breast Cancer by Combined use of RNA interference (RNAi) and Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC) Quantitative Proteomics, Molecular & Cellular Proteomics
  31. Whole Genome Sequence Analysis Suggests Intratumoral Heterogeneity in Dissemination of Breast Cancer to Lymph Nodes, PLOS One
  32. The prognostic role of circulating tumor cells in heavily pretreated individuals with a low life expectancy, Future Oncology
  33. ATG9A Loss Confers Resistance to Trastuzumab via c-CbI mediated Her2 Degradation, Oncotarget
  34. Strategies in functional proteomics: Unveiling the pathways to precision oncology, Cancer Letters
  35. Investigating miRNA-mRNA regulatory networks using crosslinking immunoprecipitation methods for biomarker and target discovery in cancer, Expert Review of Molecular Diagnostics
  36. Noncoding RNAs and the control of signalling via nuclear receptor regulation in health and disease, Best Practice & Research Clinical Endocrinology & Metabolism
  37. Proteome-wide dataset supporting functional study of tyrosine kinases in breast cancer, Data in Brief
  38. Sustained expression of miR-26a promotes chromosomal instability and tumorigenesis through regulation of CHFR, Nucleic Acids Research
  39. Prospective Validation of microRNA Signatures for Detecting Pancreatic Malignant Transformation in Endoscopic-Ultrasound Guided Fine-Needle Aspiration Biopsies, Oncotarget
  40. LMTK3 escapes tumour suppressor miRNAs via sequestration of DDX5, Cancer Letters
  41. microRNAs with prognostic significance in pancreatic ductal adenocarcinoma: A meta-analysis, European Journal of Cancer

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